After non-Hodgkin lymphoma, plasma cell neoplasia is the most common hematological malignancy. It is responsible for approximately 10% of all hematologic malignancies and 1% of all cancers. Solitary bone plasmacytoma (SBP) and extramedullary plasmacytoma are the two subtypes of plasma cell neoplasia. SBP has a 3-year likelihood of movement to numerous myeloma (MM) by 10.1% .Men are slightly more likely than women to have MM and African-Americans are twice as likely as Caucasians to have it.It mostly affects older people, with a median age of 69 years at diagnosis.In MM, estimates of survival vary according to eligibility for ASCT. If this is the case, the median OS is approximately 8 years and the 4-year survival rate is greater than 80%. The median OS for elderly patients (those over 75 years old) is approximately 5 years. Multiple factors must be evaluated for a more accurate prognosis estimate, starting with Durie–Salmon Staging and the International Staging System (ISS) to reflect the tumour burden in MM and moving on to the molecular subtype of MM. Particularly, secondary cytogenetic abnormalities like del (17p), gain (1q), or del (1p) should be evaluated for presence or absence.

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