Systemic sclerosis (SSc) is a connective tissue disease characterised by means of tremendous vascular dysfunction and innovative fibrosis of the pores and skin and interior organs. Several population-based SSc cohort research have suggested an extended incidence of malignancy. However, a paucity of literature has described the certain clinicopathological traits of lung most cancers in sufferers with SSc and its therapy outcome. In this study, we file the histological kind and molecular profile of SSc-associated lung most cancers and its stage of lung most cancers at presentation and cure outcome. Additionally, we additionally furnish a description of the chest imaging and data about cure modality in SSc-associated lung cancer. Results of serologic checking out have been accessible for seven of 12 cases: 5/7 antinuclear antibody positive, 3/5 scl-70 antibody tremendous and 2/5 anticentromere antibody (ACA) positive. Involved organs encompass lung in eight patients, manifested as interstitial lung disorder (ILD) in eight sufferers and pulmonary artery hypertension (PAH) in one patient; and esophagus in four patients, manifested as esophageal dysmotility. Raynaud syndrome used to be found in 9 patients, CREST syndrome was once found in two patients. All sufferers acquired glucocorticoids. Six patients obtained methotrexate, 4 obtained cyclophosphamide and two acquired mycophenolate mofetil